Brain changes in Hypothermia: Surface-versus Core-cooling in pigs

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Submitted: October 25, 2017
Published: Oct 31, 2017
DOI: 10.29328/journal.jfsr.1001011
Keywords:
Hypothermia, Surface cooling, Core cooling, Pigs, Histopathology, Aseptic meningitis, Cerebral micro dialysis

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Stig Morten Hammersborg
Departement of Anaesthesia and Intensive care, Haukeland University Hospital, Norway
Paul Husby
Departement of Anaesthesia and Intensive care, Haukeland University Hospital, Norway
Inge Morild
Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Norway
Peer Kåre Lilleng
Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway

Abstract

The process of hypothermia in the clinical setting has been practiced for 50 years and is known for its neuroprotective properties. This paper describes histopathological changes either by an ice sludge mimicking accidental hypothermia (S-group n=7) or by endovascular core-cooling (C-group n=7). Focal infiltrates of neutrophilic granulocytes were found in five of seven brains in the S-group and in one of seven brains in the C-group. These granulocytes were found in the arachnoids, in vessels, in vessel walls, and in the cerebral cortex. Fungi, bacteria, lymphocytes or plasma were not found.


This experimental study, mimicking accidental hypothermia, reported histopathologic features of aseptic inflammation. To our knowledge, such findings have not been described in hypothermic animals or humans before. We suggest that a local inflammatory response may be triggered in such cases of hypothermia.

Article Details

Hammersborg, S. M., Husby, P., Morild, I., & Lilleng, P. K. (2017). Brain changes in Hypothermia: Surface-versus Core-cooling in pigs. Journal of Forensic Science and Research, 1(2), 092–097. https://doi.org/10.29328/journal.jfsr.1001011
Research Articles

Copyright (c) 2017 Hammersborg SM, et al.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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