Anatomical Distribution of Intramuscular Lipomas

N K Sferopoulos*

Published: 19 April, 2017 | Volume 1 - Issue 1 | Pages: 035-039

Lipomas are the most common type of soft tissue tumor occurring in the subcutaneous tissue. Rarely, lipomas present in the deep soft tissue such as intermuscular, intramuscular, and parosteal sites. When they occur within a skeletal muscle they are called intramuscular lipomas. Intramuscular lipomas may involve both children and adults. They are benign, nontender, deep located, circumscribed but unencapsulated lesions. Intramuscular lipomas account less than 1% of all lipomas. Most are located within a single muscle (solitary), while cases involving two or more muscles are very rare. They present with typical histological features. They may be divided into the infiltrative, the well-circumscribed and the mixed type. Differential diagnosis of the infiltrative type from liposarcoma is very difficult. Local recurrence may be evident if the surgical margin is not clear. They can occur in almost any anatomical site [1-15].

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  1. Bennhoff DF, Wood JW. Infiltrating lipomata of the head and neck. Laryngoscope. 1978; 88: 839-848. Ref.: https://goo.gl/45orO9
  2. Austin RM, Mack GR, Townsend CM, Lack EE. Infiltrating (intramuscular) lipomas and angiolipomas. A clinicopathologic study of six cases. Arch Surg. 1980; 115: 281-284. Ref.: https://goo.gl/AJLW5I
  3. Pollack S, Steinfeld AD. Radiographic diagnosis of intramuscular lipoma. R I Med J. 1984; 67: 129-130. Ref.: https://goo.gl/Hb1bVf
  4. Caprio F, Lanza R, Amoroso L, Manzotti M, Cerioni M, et al. Computed tomographic findings and clinicopathologic features of intramuscular lipoma. Rays. 1985; 10: 39-42. Ref.: https://goo.gl/lLjDZQ
  5. Fletcher CD, Martin-Bates E. Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology. 1988; 12: 275-287. Ref.: https://goo.gl/udKU6x
  6. Harrington AC, Adnot J, Chesser RS. Infiltrating lipomas of the upper extremities. J Dermatol Surg Oncol 1990; 16: 834-837. Ref.: https://goo.gl/kNvt08
  7. Schellong H, Falcone A, Günther M, Schmidt H. [Infiltrating intramuscular lipoma]. Chirurg. 1997; 68: 279-282. Ref.: https://goo.gl/hESRDy
  8. Matsumoto K, Hukuda S, Ishizawa M, Chano T, Okabe H. MRI findings in intramuscular lipomas. Skeletal Radiol. 1999; 28: 145-152. Ref.: https://goo.gl/v5cozv
  9. Allen B, Rader C, Babigian A. Giant lipomas of the upper extremity. Can J Plast Surg. 2007; 15: 141-144. Ref.: https://goo.gl/qHrIkJ
  10. Bandeca MC, de Pádua JM, Nadalin MR, Ozório JE, Silva-Sousa YT, et al. Oral soft tissue lipomas: a case series. J Canad Dental Assoc. 2007; 73: 431-434. Ref.: https://goo.gl/MRFWPR
  11. Ott I, Sturm K, Losenhausen H, Issing PR. Intramuscular lipoma. A differential diagnosis of great prognostic relevance. HNO. 2009; 57: 1121-1125. Ref.: https://goo.gl/xLWMQ7
  12. Su CH, Hung JK, Chang IL. Surgical treatment of intramuscular, infiltrating lipoma. Int Surg 2011; 96: 56-59. Ref.: https://goo.gl/eIa7FR
  13. Ramos-Pascua LR, Guerra-Álvarez OA, Sánchez-Herráez S, Izquierdo-García FM, Maderuelo-Fernández JÁ. Intramuscular lipomas: Large and deep benign lumps not to underestimated. Review of a series of 51 cases. Rev Esp Cir Ortop Traumatol. 2013; 57: 391-397. Ref.: https://goo.gl/93THgM
  14. Han HH, Choi JY, Seo BF, Moon SH, Oh DY, et al. Treatment for intramuscular lipoma frequently confused with sarcoma: a 6 year restrospectivestudy and literature review. Biomed Res Int. 2014. Ref.: https://goo.gl/JKAB4u
  15. McTighe S, Chernev I. Intramuscular lipoma: a review of the literature. Orthop Rev (Pavia). 2014; 6: 5618. Ref.: https://goo.gl/1hK39Q
  16. Garavaglia J, Gnepp D. Intramuscular (infiltrating) lipoma of the tongue. Oral Surg Oral Med Oral Pathol. 1987; 63: 348-350. Ref.: https://goo.gl/g5jusy
  17. Takeda Y. Intramuscular lipoma of the tongue: report of a rare case. Ann Dent. 1989; 48: 22-24. Ref.: https://goo.gl/7SlFg5
  18. Keskin G, Ustundag E, Ercin C. Multiple infiltrating lipomas of the tongue. J Laryngol Otol. 2002; 116: 395-397. Ref.: https://goo.gl/B9Gu5k
  19. Collela G, Lanza A, Rossiello L, Rossiello R. Infiltrating lipoma of the tongue. Oral Oncology Extra. 2004; 40: 33-35. Ref.: https://goo.gl/6OM7n9
  20. Akbulut M, Aksoy A, Bir F. Intramuscular lipoma of the tongue: a case report and review of the literature. Aegean Pathol. 2005; 2: 146-9. Ref.: https://goo.gl/qjzgia
  21. Chung JC, Ng RW. A huge tongue lipoma. Otolaryngol Head Neck Surg. 2007; 137: 830-831. Ref.: https://goo.gl/USxjOl
  22. Colella G, Biondi P, Caltabiano R, Vecchio GM, Amico P, et al. Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J. 2009; 2: 7906. Ref.: https://goo.gl/J24yj5
  23. Garg M, Aggarwal R, Rajeev S. Intramuscular lipoma of tongue. J Cutan Aesthet Surg. 2011; 4: 152-153. Ref.: https://goo.gl/X9xV8i
  24. Amirzedeh A, Klaustermeyer W. Intramuscular lipoma of the tongue masquerading as angioedema. Ear, Nose Throat J. 2013; 92: E4-E5. Ref.: https://goo.gl/Z6jQ08
  25. Dattilo DJ, Ige JT, Nwana EJ. Intraoral lipoma of the tongue and submandibular space: report of a case. J Oral Maxillofac Surg. 1996; 54: 915-917. Ref.: https://goo.gl/j0dCmP
  26. Piattelli A, Fioroni M, Rubini C. Intramuscular lipoma of the cheek: a case report. J Oral Maxillofac Surg. 2000; 58: 817-819. Ref.: https://goo.gl/PcIYJX
  27. Vincent J, Baker P, Grischkan J, Fernandez Faith E. Subcutaneous midline nasal mass in an infant due to an intramuscular lipoma. Pediatr Dermatol. 2017. Ref.: https://goo.gl/FZley9
  28. Tsumuraya G, Yamada H, Shimizu H, Hamada Y. Intramuscular lipoma in the masseter muscle: a case report. Br J Oral Maxillofac Surg. 2014; 52: e21-e23. Ref.: https://goo.gl/OjsN5A
  29. Uemura T, Suse T, Yokoyama T, Mitsukawa N, Yoshikawa A. Intramuscular benign lipoma of the temporalis muscle. Scand J Plast Reconstr Surg Hand Surg. 2002; 36: 231-234. Ref.: https://goo.gl/OXGcYf
  30. Ban M, Kitajima Y. Intramuscular lipoma within the temporal muscle. Int J Dermatol. 2002; 41: 689-690. Ref.: https://goo.gl/mDFW00
  31. Charles NC, Palu RN. Intramuscular lipoma of the eyelid. Ophthalmic Surg Lasers. 2000; 31: 340-341. Ref.: https://goo.gl/HkxLza
  32. Dutton J, Wright J. Intramuscular lipoma of the superior oblique muscle. Orbit. 2006; 25: 227-233. Ref.: https://goo.gl/bIEvRT
  33. Hristodulopulos V, Medel R. Intramuscular lipoma of superior rectus muscle. Ophthal Plast Reconstr Surg. 2016; 32: e52-e55. Ref.: https://goo.gl/E88v0k
  34. Shiraki K, Kamo M, Sai T, Kamo R. Rare site for an intramuscular lipoma. Lancet. 2002; 359: 2077. Ref.: https://goo.gl/E5PqSU
  35. Lerosey Y, Choussy O, Gruyer X, François A, Marie JP, et al. Infiltrating lipoma of the head and neck: a report of one pediatric case. Int J Pediatr Otorhinolaryngol. 1999; 47: 91-95. Ref.: https://goo.gl/cUvk54
  36. Pichierri A, Marotta N, Raco A, Delfini R. Intramuscular infiltrating lipoma of the longus colli muscle: a very rare cause of neck structures compression. Cent Eur Neurosurg. 2010; 71: 157-159. Ref.: https://goo.gl/xtwfqj
  37. Mattel SF, Persky MS. Infiltrating lipoma of the sternocleidomastoid muscle. Laryngoscope 1983; 93: 205-207. Ref.: https://goo.gl/XRPbEV
  38. Moumoulidis I, Durvasula P, Jani P. Well-circumscribed intramuscular lipoma of the sternocleidomastoid muscle. Auris Nasus Larynx. 2004; 31: 283-285. Ref.: https://goo.gl/AoYRQ0
  39. Ozcan C, Gorur K, Talas D, Aydin O. Intramuscular benign lipoma of the sternocleidomastoid muscle: a rare cause of neck mass. Eur Arch Otorhinolaryngol. 2005; 262: 148-150. Ref.: https://goo.gl/cq3chV
  40. Sohn W, Kim JH, Jung SN, Kwon H, Cho KJ. Intramuscular lipoma of the sternocleidomastoid muscle. J Craniofacial Surg. 2010; 21: 1976-1978. Ref.: https://goo.gl/XdMKNb
  41. Dattolo RA, Nesbit GM, Kelly KE, Cupp CL. Infiltrating intramuscular lipoma of the paraspinal muscles. Ann Otol Rhinol Laryngol. 1995; 104: 582-584. Ref.: https://goo.gl/zqOgQ0
  42. Senchenkov A, Werning J, Staren E. Radiographic assessment of the infiltrating retropharyngeal lipoma. Otolaryngol Head Neck Surg. 2001; 125: 658-660. Ref.: https://goo.gl/da7kQ3
  43. Deschler DG, Lee K, Tami TA. Laryngeal infiltrating intramuscular lipoma. Otolaryngol Head Neck Surg. 1993; 108: 374-377. Ref.: https://goo.gl/s3F6HK
  44. Takamori S. Miwa K. Hayashi A, Shirouzu K. Intramuscular lipoma in the chest wall. Eur J Cardiothorac Surg. 2004; 26: 1038. Ref.: https://goo.gl/AWOfdz
  45. Lee JH, Do HD, Lee JC. Well-circumscribed type of intramuscular lipoma in the chest wall. J Cardiothorac Surg. 2013; 8: 181. Ref.: https://goo.gl/DtFCqE
  46. Hwang J, Jo WM, Min BJ, Shin JS. Deep-seated intramuscular lipoma penetrates the intercostal muscle. J Thorac Dis. 2015; 7: E493-E495. Ref.: https://goo.gl/Mkm2BS
  47. Gopal U, Patel MH, Wadhwa MK. Intramuscular lipoma of the pectoralis major muscle. J Postgraduate Med. 2002; 48: 330-331. Ref.: https://goo.gl/VP7V4B
  48. Pant R, Poh ACC, Hwang SG. An unusual case of an intramuscular lipoma of the pectoralis major muscle simulating a malignant breast mass. Annals Academy of Medecine Singapore. 2005; 34: 275-276. Ref.: https://goo.gl/Q2XzC9
  49. D’Alfonso TM, Shin SJ. Intramuscular lipoma arising within the pectoralis major muscle presenting as a radiographically detected breast mass. Arch Pathol Lab Med. 2011; 135: 1061-1063. Ref.: https://goo.gl/uvkeCU
  50. Oyama N, Oyama N, Komatsu H, Okita K, Yonezawa K, et al. Left ventricular asynchrony caused by an intramuscular lipoma: computed tomographic and magnetic resonance detection. Circulation. 2003; 107: e200-e2001. Ref.: https://goo.gl/DwEMOg
  51. Kindblom LG, Angervall L, Stener B, Wickbom I. Intermuscular and intramuscular lipomas and hibernomas. A clinical, roentgenologic, histologic, and prognostic study of 46 cases. Cancer. 1974; 33: 754-762. Ref.: https://goo.gl/FyWSPj
  52. Bjerregaard P, Hagen K, Daugaard S, Kofoed H. Intramuscular lipoma of the lower limb. Long-term follow-up after local resection. J Bone Joint Surg Br. 1989; 71: 812-815. Ref.: https://goo.gl/hlP8Ie
  53. Gutknecht DR. Painful intramuscular lipoma of the thigh. South Med J. 2004; 97: 1121-1122. Ref.: https://goo.gl/UixNvt
  54. Ezirmik N, Yildiz K. Deep intramuscular lipoma in thigh. Med J Bakirkoy. 2011; 7: 167-169.
  55. Grandbois L, Vade A, Lim-Dunham J, Al-Masri H. MRI findings of an intermuscular lipoma in a 2-year-old. Pediatr Radiol. 2006; 36: 974-976. Ref.: https://goo.gl/X8iVSV
  56. Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC, et al. Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology. 2002; 224: 99-104. Ref.: https://goo.gl/k3DgcW
  57. Bassett MD, Schuetze SM, Disteche C, Norwood TH, Swisshelm K, et al. Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities. The role of cytogenetics in classification and prognostication. Cancer. 2005; 103: 409-416. Ref.: https://goo.gl/6cVVKA
  58. Nishida J, Morita T, Ogose A, Okada K, Kakizaki H, et al. Imaging characteristics of deep-seated lipomatous tumors: intramuscular lipoma, intermuscular lipoma, and lipoma-like liposarcoma. J Orthop Sci. 2007; 12: 533-541. Ref.: https://goo.gl/2pG6Ap
  59. Lahrach K, el Kadi KI, Mezzani A, Marzouki A, Boutayeb F. An unusual case of an intramuscular lipoma of the biceps brachii. Pan African Med J. 2013; 15: 40. Ref.: https://goo.gl/2VHSgu
  60. Balabram D, Cabral CC, Filho OdeP, Barros CP. Intramuscular lipoma of the subscapularis muscle. Sao Paulo Med J. 2014; 132: 65-67. Ref.: https://goo.gl/YH22uD
  61. Warner JJ, Madsen N, Gerber C. Intramuscular lipoma of the deltoid causing shoulder pain: report of two cases. Clin Orthop Relat Res. 1990; 253: 110-112. Ref.: https://goo.gl/vdC7jm
  62. Ramos Pascua L, Alonso León A, Santos Sánchez JA, Ferrández Portal L. Intramuscular lipoma of the deltoid mimicking a sarcoma. A case report. Chir Organi Mov. 2001; 86: 153-157. Ref.: https://goo.gl/DxtQvg
  63. Kapetanakis S, Papathanasiou J, Dermon A, Dimitrakopoulou A, Ververidis A, et al. Unusual intramuscular lipoma of the deltoid muscle. Folia Med. 2010; 52: 68-71. Ref.: https://goo.gl/3w1kx5
  64. Egea Martinez JM, Mena JF. Lipoma of the supraspinatus muscle causing impingement syndrome a case report. J Shoulder Elbow Surg. 2009; 18: 3-5. Ref.: https://goo.gl/nLNTVG
  65. Ferrari L, Haynes P, Mack J, DiFelice GS. Intramuscular lipoma of the supraspinatus causing impingement syndrome. Orthopedics 2009; 32: 601. Ref.: https://goo.gl/3AwqjK
  66. Sungur N, Kilinç H, Ozdemr R, Sensöz O. An infiltrating intramuscular lipoma of the brachioradialis muscle. Ann Plast Surg. 2001; 46: 353-354. Ref.: https://goo.gl/2GqsxT
  67. Coraci D, Santilli V, Padua L. Painful Intramuscular Lipoma of the Infraspinatus: Unusual Location and Presentation. Orthopedics. 2016; 39: 206. Ref.: https://goo.gl/B8eyVO
  68. Cappellini O. A case of dissociated paralysis of the radial nerve caused by intramuscular lipoma. Chir Organi Mov. 1958; 45: 338-343. Ref.: https://goo.gl/CMvl0k
  69. Manes E. On a case of dissociated paralysis of the radial nerve caused by intramuscular lipoma. Osp Ital Chir. 1968; 19: 165-172. Ref.: https://goo.gl/OdNYnB
  70. Allagui M, Maghrebi S, Touati B, Koubaa M, Hadhri R, et al. Posterior interosseous nerve syndrome due to intramuscular lipoma. Eur Orthop Traumatol. 2014; 5: 75-79. Ref.: https://goo.gl/oO4eie
  71. Feng A, Igolnikov I, Brown CH, Weinik MM. Poster 197-E Hip Pain Secondary to Intramuscular Lipoma of Tensor Fascia Lata: A Case Report. PM R. 2016; 8: S329-S330. Ref.: https://goo.gl/ct6reN
  72. Cossey AJ, Stranks GJ. Intramuscular lipoma in an anomalous muscle belly of the middle finger lumbrical as a cause of carpal tunnel syndrome and trigger wrist. Orthopedics. 2003; 26: 85-86. Ref.: https://goo.gl/xAeGS0
  73. Berlund P, Kalamaras M. A case report of trigger wrist associated with carpal tunnel syndrome caused by an intramuscular lipoma. Hand Surg. 2014; 19: 237-239. Ref.: https://goo.gl/yUtJ5Z
  74. Aldredge WM, Halpert B. Lipoma of the thenar. Surgery. 1948; 24: 853. Ref.: https://goo.gl/Xpx8hs
  75. Zamora MA, Zamora CA, Samayoa EA, Morales HA, Ceballos JF. High-resolution ultrasonography in an aggressive thenar intramuscular lipoma. J Ultrasound Med. 2005; 24: 1151-1155. Ref.: https://goo.gl/9sCYkU
  76. Mohan L, Semoes J. Thenar intramuscular lipoma: an unusual case. Internet J Surg. 2008; 17:1-3. Ref.: https://goo.gl/Jl17JE
  77. Chernev I, Tingey S. Thenar intramuscular lipoma: A case report. J Med Cases. 2013; 4: 676-678. Ref.: https://goo.gl/XGIjfg
  78. Papakostas T, Tsovilis AE, Pakos EE. Intramuscular lipoma of the thenar: A Rare Case. Arch Bone Jt Surg. 2016; 4: 80-82. Ref.: https://goo.gl/cwB00v
  79. Lee YH, Jung JM, Baek GH, Chung MS. Intramuscular lipoma in thenar or hypothenar muscles. Hand Surg. 2004; 9: 49-54. Ref.: https://goo.gl/EdOM1t
  80. Lui TH. Intramuscular lipoma of abductor digiti minimi mimicking intramuscular haemangioma. BMJ Case Rep. 2013. Ref.: https://goo.gl/f0nDgL
  81. Rispoli L, Singh JR, Piesco J. Unusual location of intramuscular lipoma presenting as an extensor tendon tear: A diagnostic dilemma. Am J Phys Med Rehabil. 2017. Ref.: https://goo.gl/opvxXy
  82. Kalmar G, Doobay N. Intramuscular lipoma of the flexor hallucis brevis muscle. A case report. J Am Podiatr Med Assoc. 2017; 107: 80-84. Ref.: https://goo.gl/ftTLjS


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